Biotin

Biotin (Figure 1) can be used as an oligonucleotide modification for a variety of assays. Moieties or surfaces conjugated with streptavidin will bind Biotin-labelled oligos tightly.

Figure 1. Structure of 5'-Biotin (R = sequence).

metabion offers Biotin as a 5'-, 3'- or internal modification in its standard DNA and RNA portfolio:

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References

Fang X., Liu X., Schuster S., Tan W. Designing a novel molecular beacon for surface-immobilized DNA hybridization studies. J Am Chem Soc, 1999, 121(12): 2921–2922.