Biotin-TEG

Biotin can be used as an oligonucleotide modification for a variety of assays. Moieties or surfaces conjugated with streptavidin will bind Biotin-labelled oligos tightly. Additionally, the TEG spacer minimizes steric hindrance between the Biotin moiety and the oligonucleotide (Figure 1). This, for example, facilitates the capture of Biotin-labelled oligos onto streptavidin coated surfaces.

Figure 1. Structure of 5'-Biotin-TEG (R = sequence).

metabion offers Biotin-TEG as a 5'-, 3'- or internal modification in its standard DNA and RNA portfolio:

For more information, please visit our Portfolio. To place an order, click here.


References

Fang X., Liu X., Schuster S., Tan W. Designing a novel molecular beacon for surface-immobilized DNA hybridization studies. J Am Chem Soc, 1999, 121(12): 2921–2922.