Cholesteryl-TEG

Cholesteryl-TEG (Figure 1) is often used to increase the cell uptake of oligonucleotide. This modification has been shown to elicit cell uptake both in vitro and in vivo (1).

Figure 1. Structure of 5'-Cholesteryl-TEG (R = sequence).

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References

1. Wolfrum C., Shi S., Jayaprakash KN., Jayaraman M., Wang G., Pandey RK., Rajeev KG., Nakayama T., Charrise K., Ndungo EM., Zimmermann T., Koteliansky V., Manoharan M., Stoffel M. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nat Biotechnol. 2007 Oct;25(10):1149-57.