DBCO-TEG (Figure 1) is usually used in copper-free click reactions, where DBCO-TEG-modified oligos and azide modifiers are conjugated in organic solvents, such as DMSO, or aqueous buffers. With DBCO-TEG, a TEG spacer separates the oligonucleotide from the DBCO, and from the Azide modifier, once the “click” reaction is complete. metabion offers DBCO-TEG as a modification in its DNA portfolio.
![](https://www.metabion.com/uploads/5-DBCO-TEG.png.pagespeed.ce.sN1f2x_pIZ.png)
Figure 1. Structure of 5'-DBCO-TEG (R = sequence).
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References