Cholesteryl-TEG is often used to increase the cell uptake of oligonucleotide. This modification has been shown to elicit cell uptake both in vitro and in vivo.

CellUptake Cholesteryl TEG

Metabion offers Cholesteryl-TEG in its standard DNA and RNA portfolio. Click here

MW 5' 683 g/mol
MW 3' 756 g/mol


C. Wolfrum, S. Shi, K.N. Jayaprakash, M. Jayaraman, G. Wang, R.K. Pandey, K.G. Rajeev, T. Nakayama, K. Charrise, E.M. Ndungo, T. Zimmermann, V. Koteliansky, M. Ma. Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nature Biotechnology. 25, 2007, 1149 - 1157.


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