DBCO-TEG is usually used in copper-free click reactions, where DBCO-TEG-modified oligos and azide modifiers are conjugated in organic solvents, such as DMSO, or aqueous buffers. With DBCO-TEG, a TEG spacer separates the oligonucleotide from the DBCO, and from the Azide modifier, once the “click” reaction is complete.



Metabion offers DBCO-TEG modification in its DNA portfolio. Click here


P. van Delft , N.J. Meeuwenoord , S. Hoogendoorn , J. Dinkelaar, H.S. Overkleeft, G.A. van der Marel, D.V. Filippov. Synthesis of oligoribonucleic acid conjugates using a cyclooctyne phosphoramidite. Org Lett. 12, 2010, Bd. 23, 5486-9.


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