DBCO
DBCO is usually used in copper-free click reactions, where DBCO-modified oligos and azide modifiers are conjugated in organic solvents, such as DMSO, or aqueous buffers.
Metabion offers DBCO modification in its DNA portfolio. Click here
| DBCO as a 5' modification | |
|---|---|
| MW | 495 g/mol |
| Extinction coefficient (260nm) | 7 mM-1cm-1 |
| DBCO as an internal modification | |
|---|---|
| MW | 718.37 g/mol |
| Extinction coefficient (260nm) | 16.3 mM-1cm-1 |
| DBCO as a 3' modification | |
|---|---|
| MW | 525 g/mol |
| Extinction coefficient (260nm) | 7 mM-1cm-1 |
P. van Delft , N.J. Meeuwenoord , S. Hoogendoorn , J. Dinkelaar, H.S. Overkleeft, G.A. van der Marel, D.V. Filippov. Synthesis of oligoribonucleic acid conjugates using a cyclooctyne phosphoramidite. Org Lett. 12, 2010, Bd. 23, 5486-9.