DBCO is usually used in copper-free click reactions, where DBCO-modified oligos and azide modifiers are conjugated in organic solvents, such as DMSO, or aqueous buffers.

Click DBCO

Metabion offers DBCO modification in its DNA portfolio. Click here

DBCO as a 5' modification
MW 495 g/mol
Extinction coefficient (260nm) 7 mM-1cm-1
DBCO as an internal modification
MW 718.37 g/mol
Extinction coefficient (260nm) 16.3 mM-1cm-1
DBCO as a 3' modification
MW 525 g/mol
Extinction coefficient (260nm) 7 mM-1cm-1


P. van Delft , N.J. Meeuwenoord , S. Hoogendoorn , J. Dinkelaar, H.S. Overkleeft, G.A. van der Marel, D.V. Filippov. Synthesis of oligoribonucleic acid conjugates using a cyclooctyne phosphoramidite. Org Lett. 12, 2010, Bd. 23, 5486-9.

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