2’-Deoxyuridine can be incorporated in DNA oligonucleotides as an analog of dT. This base can be removed by treatment with uracil-N-deglycosylase (UNG), which is normally used to digest amplified DNA and eliminate DNA-RNA cross-contamination.

2’-Deoxyuridine modified oligos can be used to study adaptive and innate immunity in animals.

ModifiedBasis 2 Deoxyuridine

Metabion offers 2’-Deoxyuridine in its DNA and RNA portfolio. Click here

MW 290 g/mol
Extinction coefficient (260 nm) 10 mM-1cm-1


M.S. Neuberger, R.S. Harris, J. Di Noia, S.K. Petersen-Mahrt. Immunity through DNA deamination. Trends Biochem. Sci. (2003), 28: 305-312.

R.S. Harris, A.M. Sheehy, H.M. Craig, M.H. Malim, M.S. Neuberger. DNA deamination: not just a trigger for antibody diversification but also a mechanism for defense against retroviruses. Nature Immunology (2003), 4: 641-643.

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