Bromo-dA
8-Bromo deoxyadenine (Bromo-dA) is a halogenated nucleotide, commonly used in X-ray crystallography to facilitate the determination of DNA structure. Additionally, they are photo-labile and therefore suitable for UV-crosslinking experiments to study protein-DNA complexes. 5-Br-dU was also used to create photo-aptamers able to crosslink with their target.
Metabion offers the modification in its DNA and RNA portfolio. Click here
| Specifications | |
|---|---|
| MW | 392.1 g/mol |
| Extinction coefficient (260 nm) | 14.8 mM-1cm-1 |
W. Hendrickson, C. Ogata. Phase determination from multiwavelength anomalous diffraction measurements. Meth. Enzymol. (1997), 276: 494-523.